The nucleic acid sampling safe cabin is a product designed specifically for throat swab and nasal swab sampling work. The equipment sends clean and safe air into the internal space through the configured ventilation and purification system, and maintains a relatively positive pressure inside. By constructing an isolated positive pressure space, the air inside the cabin is isolated from the outside, preventing external air from entering the cabin and effectively protecting the safety of internal medical staff from infection due to sampling work. While ensuring safety, it improves the operational flexibility and comfort of medical staff, saves testing time, and enhances testing efficiency.